TREATMENT OF VAGINAL INTRAEPITHELIAL...

... Neoplasia (Primarily Low Grade) With Imiquimod 5 % Cream- An Updated Report

Fuente: Treatment of vaginal intraepithelial Neoplasia
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Buck HW, Watkins Memorial Student Health Center, University of Kansas, Lawrence, KS

OBJECTIVE:

Treatment of human papillomavirus (HPV) associated vaginal lesions (Vaginal intraepithelial neoplasia, VAIN) can be expensive, tedious and morbidity inducing. Imiquimod 5% cream, a safe and effective treatment of external genital warts, enhances the immune response to HPV infection.

METHODS:

Initial experience treating VAIN in 56 young women with imiquimod cream was reported in J Lower Gen Tract Dis 2003;4:290-293. 28 additional patients have been managed. A treatment course was 1 sachet of imiquimod 5% cream (0.25g) applied via vaginal applicator once weekly for 3 doses.

RESULTS:

The basic data of the initial group, the additional patients, and the groups combined are as follows

More than 1 course: 2 courses: 10 patients; 3:1; 4:1; 6:1

CONCLUSIONS:

Additional experience continues to evidence to evidence the advantages of a very low dosing regimen of imiquimod 5% cream in the treatment of VAIN because of its simplicity of use, its high degree of effectiveness after a short treatment course, and the relative absence of associated adverse events.

KEY WORDS:

Vaginal intraepithelial neoplasia, immune response modifier, imiquimod 5% cream.